Guy Haskin Fernald, Ph.D.


Interests Data science, machine learning, biomedical informatics, drug repositioning, and drug discovery.


Professional Experience

Foresite Labs Senior Staff Data Scientist
San Francisco, California 2018 - present

At Foresite I am building data pipelines and developing novel machine learning pipelines that aggregate and integrate large-scale genomic, biological, and pharmacological datasets to identify and incubate investment opportunities in biomedicine.

Vium Data Scientist, Researcher, Developer
San Mateo, California 2016 - 2018

Designing and developing novel metrics, algorithms, and statistical methods for a cloud-based software system. Writing production software, implementing machine learning methods, and authoring tools to analyze pre-clinical data from drug studies using large data sets generated from high-volume, continuously monitored sensors.

Tech Consultant and Developer Data Scientist, Developer
San Francisco, California 2015

Investigated commercial applications of biomedical research. Developed software using R, Python, and AWS to analyze biological and chemical data sets and create pipelines to enable and support drug discovery. Performed due diligence and invested in tech and biotech startups.

Stanford University Graduate Researcher and Instructor
Stanford, California 2007 - 2014

Conceived and conducted original research ideas, developed software in R and Python on a cluster and using AWS. Analyzed and investigated hypotheses on large scale biomedical, genetic, and chemical datasets. Taught and mentored students in bioinformatics and data analysis. Coordinated and collaborated with external research groups.

University of California, San Francisco Research Associate
San Francisco, California 2004 - 2007

Investigated the role of genetic linkage and gene expression in multiple sclerosis and experimental autoimmune encephalomyelitis through statistical methods, network analysis, and computer modeling.

Instituto Nacional de Salud Publica
(National Public Health Institute)
Technical Consultant
Cuernavaca, Mexico 2001 - 2003

Developed direction and managed the implementation of internal and external computer resources for the health economics group. Worked in Spanish and English.

Ariba (acquired by SAP) Manager and Engineer
Sunnyvale, California 1996 - 2001

Member of original technical team that developed patented purchasing system. Worked on first six versions of released software. Managed team of programmers that implemented internationalization, management tools, and web applications.

Netmarket (acquired by Trilegiant) Founder and Chief Programmer
Cambridge, Massachusetts 1993 - 1996

Co-founded software startup, hired engineers, and led software development efforts. Wrote software for first music CD store on the web, as featured in the New York Times.


Patents Adams N, Brown M, Carlstrom B, Elkin B, Hegarty P, Haskin G, Putanec B. Operating resource management system. US Patent no. 7,117,165, October 3, 2006.

Tatonetti N, Altman R, Fernald G Haskin. Signal Detection Algorithms to Identify Drug Effects and Drug Interactions. Patent pending. US Patent Application July 28, 2016


Education

Stanford University, Stanford, CA  2007 - 2014

  • Ph.D. and M.S. in Biomedical Informatics. Dissertation: Connecting chemical features of drugs to molecular, cellular, and organismal phenotypes. Funded by NIH LM07033 and R24GM61374. Coursework included translational medicine, genetics, pharmacogenomics, and biostatisics.

  • M.S. in Medicine. Howard Hughes Medical Institute training program for translational medicine. Coursework covered the first two years of a Medical Degree including anatomy, physiology, immunology, pathology, and human health and disease.

    Swarthmore College, Swarthmore, PA  1990 - 1994

  • B.A. in Mathematics and Computer Science. Additional courses at the University of Edinburgh.


  • Publications

    Karczewski, KJ, Fernald, GH, et al. STORMSeq: an open-source, user-friendly pipeline for processing personal genomics data in the cloud. PLoS One 2014, 9(1):e84860.

    Fernald GH and Altman RB. Using molecular features of xenobiotics to predict hepatic gene expression response. J Am Med Inform Assoc. 2012 Jun 14.

    Fernald GH, Capriotti E, Daneshjou R, Karczewski KJ, Altman RB. Bioinformatics Challenges for Personalized Medicine. Bioinformatics (2011) 27 (13): 1741-1748.

    Tatonetti NP, Denny JC, Murphy SN, Fernald GH, Krishnan G, Castro V, Yue P, Tsau PS, Kohane I, Roden DM, and Altman RB. Detecting drug interactions from adverse-event reports: interaction between paroxetine and pravastatin increases blood glucose levels. Clinical Pharmacology and Therapeutics (2011) 90 1, 133-142.

    Han MH, Hwang SI, Roy DB, Lundgren DH, Price JV, Ousman SS, Fernald GH, Gerlitz B, Robinson WH, Baranzini SE, Grinnell BW, Raine CS, Sobel RA, Han DK, Steinman L. Proteomic analysis of active multiple sclerosis lesions reveals therapeutic targets. Nature. 2008 Feb 28;451(7182):1076-81.

    Fernald GH, Pachner A, Caillier S, Narayan K, Oksenberg JR, Baranzini SE. Genome-Wide Network Analysis Reveals the Global Properties of IFN-beta Immediate Transcriptional Effects in Humans.J Immunol. 2007 Apr 15;178(8):5076-85.

    Fernald GH, Yeh RF, Hauser SL, Oksenberg JR, Baranzini SE. 2005. Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis. J Neuroimmunol 167(1-2):157-69.


    Honors and Awards

  • National Science Foundation GRFP Honorable Mention, 2009.
  • National Library of Medicine Training Grant Recipient, 2008.
  • Phi Beta Kappa, 1994.
  • Bachelor of Arts awarded with Distinction, 1994.


  • Technical Skills

  • Programming Experience: scientific programming, data science and data engineering, pipeline development, infrastructure development.
  • Languages: Python, R, Scala, Spark, Terraform, SQL, C, LaTeX, Unix shell programming.
  • Platforms: AWS, GCP, Unix.


  • Interests and Skills

  • Activities and skills: Spanish language, cooking (Certificate in Culinary Arts from the French Culinary Institute, New York City), classical guitar, and tennis.
  • Board member: San Francisco Works (previous), Mission Learning Center (previous).